Sie sind hier: Publikationen

2018

Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam D, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L. H19 Induces Abdominal Aortic Aneurysm Development and Progression. Circulation. 2018 Apr

Ziegler KA, Ahles A, Wille T, Kerler J, Ramanujam D, Engelhardt S. Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice. Cardiovasc Res. 2018 Feb

2017

Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA. i is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. Nat Commun. 2017 Nov

Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nat Commun. 2017 Nov

Engelhardt S, Buder A, Pfeil K, Schwittlick U, Klas E, Hinney B, Aupperle-Lellbach H, Pfeil I. [Nephritis in a Staffordshire Terrier puppy caused by Encephalitozoon cuniculi genotype I]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2017 Nov

Toischer K, Zhu W, Hünlich M, Mohamed BA, Khadjeh S, Reuter SP, Schäfer K, Ramanujam D, Engelhardt S, Field LJ, Hasenfuss G. Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload. J Clin Invest. 2017 Dec

Werfel S, Leierseder S, Ruprecht B, Kuster B, Engelhardt S. Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation. Nucleic Acids Res. 2017 Sep

Hinz, L., Ahles, A., Ruprecht, B., Küster, B., Engelhardt, S. Two serines in the distal C-terminus of the human β1-adrenoceptor determine β-arrestin2 recruitment. PLoS ONE 12(5),e0176450, 2017

Devaux Y., Creemers EE., Boon RA., Werfel S., Thum T., Engelhardt S., Dimmeler S., Squire I. Circular RNAs in heart failure. European Journal of Heart Failure 2017

Poller W., Dimmeler S., Heymans S., Zeller T., Haas J., Karakas M., Leistner DM., Jakob P., Nakagawa S., Blankenberg S., Engelhardt S., Thum T., Weber C., Meder B., Hajjar R., Landmesser U., Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives. Eur Heart J. 2017 Apr 18. doi: 10.1093/eurheartj/ehx165.

2016

Angermeier E., Domes K., Lukowski R., Schlossmann J., Rathkolb B., Angelis MH., Hofmann F. Iron deficiency anemia in cyclic gmp kinase knockout mice. Haematologica 101(2), pp. e48-e51. 2016

Patriarchi T., Qian H., Di Biase V., Malik ZA., Chowdhury D., Price JL., Hammes EA., Buonarati OR., Westenbroek RE., Catterall WA., Hofmann F., Xiang YK., Murphy GG., Chen CY., Navedo MF., Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO Journal 35(12), pp. 1330-1345. 2016

Wetzl V., Schinner E., Kees F., Hofmann F., Faerber L., Schlossmann J. Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin. Frontiers in Pharmacology 7(JUL),195. 2016.

Ramanujam D, Sassi Y, Laggerbauer B, Engelhardt S. Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart. Mol Ther. 2016 Oct 4. doi: 10.1038/mt.2016.166. 

Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S. Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. J Mol Cell Cardiol. 2016 Oct;99:57-64. doi: 10.1016/j.yjmcc.2016.08.010. Epub 2016 Aug 15.

Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T. Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. Neuron. 2016 Oct 18. pii: S0896-6273(16)30654-7. doi: 10.1016/j.neuron.2016.09.049.

Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S. Characterization of circular RNAs in human, mouse and rat hearts. J Mol Cell Cardiol. 2016 Sep;98:103-7. doi: 10.1016/j.yjmcc.2016.07.007. Epub 2016 Jul 28.

Meyer K, Hodwin B, Ramanujam D, Engelhardt S, Sarikas A. Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis. J Am Coll Cardiol. 2016 May 3;67(17):2018-28. doi: 10.1016/j.jacc.2016.02.047.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M5, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T. Long noncoding RNA Chast promotes cardiac remodeling. Sci Transl Med. 2016 Feb 17;8(326):326ra22. doi: 10.1126/scitranslmed.aaf1475.

2015

Engelhardt S, Sassi Y. MicroRNA Augmentation of Bone Marrow-Derived Cell Therapy. J Am Coll Cardiol. 2015 Nov 17;66(20):2227-9. doi: 10.1016/j.jacc.2015.09.053.

Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Döhner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK, Kuchenbauer F. MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Exp Hematol. 2015 Oct;43(10):858-868.e7. doi: 10.1016/j.exphem.2015.05.018. Epub 2015 Jul 8.

Keller K, Maass M, Dizayee S, Leiss V, Annala S, Köth J, Seemann WK, Müller-Ehmsen J, Mohr K, Nürnberg B, Engelhardt S, Herzig S, Birnbaumer L, Matthes J. Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice. Cardiovasc Res. 2015 Dec 1;108(3):348-56. doi: 10.1093/cvr/cvv235. Epub 2015 Oct 13.

Domes K, Patrucco E, Loga F, Dietrich A, Birnbaumer L, Wegener JW, Hofmann F. Murine cardiac growth, TRPC channels, and cGMP kinase I. Pflugers Arch. 2015 Oct;467(10):2229-34. doi: 10.1007/s00424-014-1682-0. Epub 2014 Dec 30.

Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J. Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration. FEBS J. 2015 Oct;282(19):3786-98. doi: 10.1111/febs.13376. Epub 2015 Jul 30.

Truong DJ, Kühner K, Kühn R, Werfel S, Engelhardt S, Wurst W, Ortiz O. Development of an intein-mediated split-Cas9 system for gene therapy. Nucleic Acids Res. 2015 Jul 27;43(13):6450-8. doi: 10.1093/nar/gkv601. Epub 2015 Jun 16.

Ramanujam D, Engelhardt S. Intercellular miRNA Traffic. Circ Res. 2015 May 22;116(11):1726-8. doi: 10.1161/CIRCRESAHA.115.306519.

Gutmann J, Kühbeck F, Berberat PO, Fischer MR, Engelhardt S, Sarikas A. Use of learning media by undergraduate medical students in pharmacology: a prospective cohort study. PLoS One. 2015 Apr 7;10(4):e0122624. doi: 10.1371/journal.pone.0122624. eCollection 2015.

Ahles A, Rodewald F, Rochais F, Bünemann M, Engelhardt S. Interhelical interaction and receptor phosphorylation regulate the activation kinetics of different human β1-adrenoceptor variants. J Biol Chem. 2015 Jan 16;290(3):1760-9. doi: 10.1074/jbc.M114.607333. Epub 2014 Dec 1.

2014

Sassi Y, Ahles A, Truong DJ, Baqi Y, Lee SY, Husse B, Hulot JS, Foinquinos A, Thum T, Müller CE, Dendorfer A, Laggerbauer B, Engelhardt S. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014 Dec;124(12):5385-97. doi: 10.1172/JCI74349. Epub 2014 Nov 17.

Friedrich FW, Reischmann S, Schwalm A, Unger A, Ramanujam D, Münch J, Müller OJ, Hengstenberg C, Galve E, Charron P, Linke WA, Engelhardt S, Patten M, Richard P, van der Velden J, Eschenhagen T, Isnard R, Carrier L. FHL2 expression and variants in hypertrophic cardiomyopathy. Basic Res Cardiol. 2014;109(6):451. doi: 10.1007/s00395-014-0451-8. Epub 2014 Oct 31.

Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA, Müller OJ. Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase. Cardiovasc Res. 2014 Oct 1;104(1):15-23. doi: 10.1093/cvr/cvu174. Epub 2014 Jul 31.

Kräenbring J, Monzon Penza T, Gutmann J, Muehlich S, Zolk O, Wojnowski L, Maas R, Engelhardt S, Sarikas A. Accuracy and completeness of drug information in Wikipedia: a comparison with standard textbooks of pharmacology. PLoS One. 2014 Sep 24;9(9):e106930. doi: 10.1371/journal.pone.0106930. eCollection 2014.

Ahles A, Engelhardt S. Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease. Pharmacol Rev. 2014 Jul;66(3):598-637. doi: 10.1124/pr.113.008219.

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014 May;124(5):2136-46. doi: 10.1172/JCI70577. Epub 2014 Apr 17.

Kühbeck F, Engelhardt S, Sarikas A. OnlineTED.com-a novel web-based audience response system for higher education. A pilot study to evaluate user acceptance. GMS Z Med Ausbild. 2014 Feb 17;31(1):Doc5. doi: 10.3205/zma000897. eCollection 2014

Yang G, Shi Y, Yu J, Li Y, Yu L, Welling A, Hofmann F, Striessnig J, Juntti-Berggren L, Berggren PO, Yang SN. CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serumCell Mol Life Sci. 2014 Oct 8. [Epub ahead of print]

Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. J Physiol. 2014 Aug 28. [Epub ahead of print]

Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, Hurwitz J, Pan ZQ, Engelhardt S, Sarikas A. Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen. Proc Natl Acad Sci U S A. 2014 Feb 18. [Epub ahead of print]

Langeslag M, Malsch P, Welling A, Kress M. Reduced excitability of gp130-deficient nociceptors is associated with increased voltage-gated potassium currents and Kcna4 channel upregulation. Pflugers Arch. 2014 Jan 25. [Epub ahead of print]

2013

Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Muehlich S, Pfeiffer AF, Field LJ, Charron MJ, Pan ZQ, Engelhardt S, Sarikas A. Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling. Cell Signal. 2014 Feb;26(2):233-9. doi: 10.1016/j.cellsig.2013.11.005. Epub 2013 Nov 9.

Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A, Mummery CL. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. EMBO J. 2013 Nov 8. doi: 10.1038/emboj.2013.240. [Epub ahead of print]

Engelhardt S, Leierseder S. Coinciding functions for miR-145 in vascular smooth muscle and cardiac fibroblasts. J Mol Cell Cardiol. 2013 Oct 17. doi:pii: S0022-2828(13)00293-9. 10.1016/j.yjmcc.2013.10.002. [Epub ahead of print] No abstract available.

Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A. microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription. PLoS One. 2013 Sep 27;8(9):e75882. doi: 10.1371/journal.pone.0075882.

Leierseder S, Petzold T, Zhang L, Loyer X, Massberg S, Engelhardt S. MiR-223 is dispensable for platelet production and function in mice. Thromb Haemost. 2013 Sep 26;110(6). [Epub ahead of print]

Milde M, Rinne A, Wunder F, Engelhardt S, Bünemann M. Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production. Biochem J. 2013 Sep 15;454(3):515-23. doi: 10.1042/BJ20130554.

Rinck A, Preusse M, Laggerbauer B, Lickert H, Engelhardt S, Theis FJ. The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance. RNA Biol. 2013 Jul;10(7):1125-35. doi: 10.4161/rna.24955. Epub 2013 May 9.

Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, Thum T, Laggerbauer B, Engelhardt S. MiR-378 Controls Cardiac Hypertrophy by Combined Repression of MAP Kinase Pathway Factors. Circulation. 2013 Apr 26. [Epub ahead of print]



Sucha M, Engelhardt S, Sarikas A. Internet discussion forums as part of a student-centred teaching concept of pharmacology. GMS Z Med Ausbild. 2013;30(1):Doc2. doi:10.3205/zma000845. Epub 2013 Feb 21.



Zollner B, Sucha M, Berg C, Muß N, Amann P, Amann-Neher B, Oestreicher D, Engelhardt S, Sarikas A. Pharmacases.de - a student-centered e-learning project of clinical pharmacology. Med Teach. 2013;35(3):251-3. doi: 10.3109/0142159X.2013.759642. Epub 2013 Jan 22.

 

 

2012

Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K, Thum T. undefinedThe miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun. 2012;3:1078. doi: 10.1038/ncomms2090.

Engelhardt S. undefinedSmall RNA biomarkers come of age. J Am Coll Cardiol. 2012 Jul 24;60(4):300-3. No abstract available

Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M. undefinedThe bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation. 2012 Feb 7;125(5):685-96. Epub 2012 Jan 5.

Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS. undefinedRegulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB J. 2012 Mar;26(3):1009-17. Epub 2011 Nov 16.

Jentzsch C, Leierseder S, Loyer X, Flohrschütz I, Sassi Y, Hartmann D, Thum T, Laggerbauer B, and Engelhardt S. A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes. J Mol Cell Cardiol. 2012 Jan;52(1):13-20. Epub 2011 Jul 23.

2011

Fiedler J, Jazbutyte V, Kirchmaier B, Galuppo P, Kneitz S, Pena JTR, Sohn-Lee C, Soutschek J, Brand T, Tuschl T, Ertl G, Engelhardt S, Bauersachs J, Thum T. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation. Epub ahead of print (2011).

Hulot JS, Fauconnier J, Ramanujam D, Chaanine A, Aubart F, Sassi Y, Merkle S, Cazorla O, Ouille A, Dupuis M, Hadri L, Jeong D, Muehlstedt S, Schmitt J, Braun A, Benard L, Saliba Y, Laggerbauer B, Nieswandt B, Lacampagne A, Hajjar R, Lompre AM, and Engelhardt S. A critical role for STIM1 in cardiac hypertrophy. Circulation. 124(7):796-805 (2011).

Ahles A, Rochais F, Frambach T, Bünemann M and Engelhardt S.A Polymorphism-Specific "Memory" Mechanism in the β2-Adrenergic Receptor. Sci. Signal. Aug 9;4(185):ra53 (2011).

Poomvanicha M, Wegener JW, Blaich A, Fischer S, Domes K, Moosmang S, Hofmann F. Facilitation and Ca2+-dependent Inactivation Are Modified by Mutation of the Cav1.2 Channel IQ Motif. J Biol Chem. 286(30), 26702-7 (2011 Jul 29).

Seizer P, Ochmann C, Schönberger T, Zach S, Rose M, Borst O, Klingel K, Kandolf R, MacDonald HR, Nowak RA, Engelhardt S, Lang F, Gawaz M, May AE. Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion. Arterioscler Thromb Vasc Biol. 31(6), 1377-86. Epub 2011 Mar 24 (2011).

Thum T, Chau N, Bhat B, Gupta SK, Linsley PS, Bauersachs J, Engelhardt S. Comparison of different miR-21 inhibitor chemistries in a cardiac disease model.J Clin Invest. 121(2), 461-2. Letter (2011).

Michalakis S,  Kleppisch T, Polta SA, Wotjak CT, Koch S, Rammes G, Matt L, Becirovic E, Biel M. Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice. Genes Brain Behav. 10(2), 137-48 (2011).

Leiss V, Friebe A, Welling A, Hofmann F, Lukowski R. Cyclic GMP kinase I modulates glucagon release from pancreatic α-cells. Diabetes. 60, 148-56 (2011).

Matt L, Michalakis S, Hofmann F, Hammelmann V, Ludwig A, Biel M, and Kleppisch T. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life Sci. 68, 125-37 (2011).

2010

Desch M, Schinner E, Kees F, Hofmann F, Seifert R, Schlossmann J. Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I. FEBS Lett. 584, 3979-84 (2010).

Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A, and Laugwitz KL. Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome. New Engl J Med. 363, 1397-409 (2010).

Thoeringer CK, Pfeiffer UJ, Rammes G, Pamplona FA, Moosmang S, Wotjak CT. Early life environment determines the development of adult phobic-like fear responses in BALB/cAnN mice. Genes Brain Behav. 9, 947-57 (2010).

Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez MM, Klug A, Traut MH, Ylera B, Tahirovic S, Hofmann F, Stein V, Moosmang S, Hentall ID, Bradke F. Electrical Activity Suppresses Axon Growth through Cav1.2 Channels in Adult Primary Sensory Neurons. Curr Biol. 20, 1154-1164 (2010).

Langwieser N, Christel CJ, Kleppisch T, Hofmann F, Wotjak CT, and Moosmang S. Homeostatic Switch in Hebbian Plasticity and Fear Learning after Sustained Loss of Cav1.2 Calcium Channels. J Neurosci. 30, 8367-8375 (2010).

Lukowski R, Rybalkin SD, Beavo JA, Hofmann F. Reply to Kass and Takimoto: Cardiac hypertrophy without cGKI and PDE5 in cardiac myocytes. PNAS. 107, E99 (2010).

Blaich A, Welling A, Fischer S, Wegener JW, Köstner K, Hofmann F, Moosmang S. Facilitation of murine cardiac L-type Cav1.2 channel is modulated by Calmodulin kinase II–dependent phosphorylation of S1512 and S1570. PNAS. 107, 10285-10289 (2010).

Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S, Humpel C, Hofmann F, Windisch M, -Günther Knaus H, Marksteiner J. L-Type Calcium Channel Ca{V} 1.2 in Transgenic Mice Overexpressing Human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) Mutations. J Alzheimers Dis. 20, 1167-1180 (2010).

Huster M, Frei E, Hofmann F, Wegener JW. A complex of CaV1.2/PKC is involved in muscarinic signaling in smooth muscle. FASEB J. 24, 2651-9 (2010).

Fernández-Tenorio M, González-Rodríguez P, Porras C, Castellano A, Moosmang S, Hofmann F, Ureña J, López-Barneo J. Genetic Ablation of L-Type Ca2+ Channels Abolishes Depolarization-Induced Ca2+ Release in Arterial Smooth Muscle. Circ Res. 106, 1285-1289 (2010).

Lukowski R, Rybalkin SD, Loga F, Leiss V, Beavo JA, Hofmann F. Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. PNAS. 107, 5646-5651 (2010).

Hofmann F. Ido brings down the pressure in systemic inflammation. Nat Med. 16, 265-267 (2010).

Paul C, Stratil C, Hofmann F, Kleppisch T. cGMP-dependent protein kinase Type I promotes CREB/CRE-mediated gene expression in neurons of the lateral amygdala. Neurosci Lett. 473, 82-86 (2010).

Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, Jochim A, Spiessberger B, Höcherl K, Feil R, Feil S, Lukowski R, Wegener JW, Hofmann F, Schlossmann J. IRAG determines NO- and ANP-mediated smooth muscle relaxation. Cardiovasc Res. 86, 496-505 (2010).

Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL. Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. FASEB J. 24, 700-711 (2010).

2009

Hofmann F & Kleppisch T. Effects of cGMP-dependent protein kinase knockouts. Handb. Cell Signaling. 1515-1518 (2009).

Frei E, Huster M, Smital P, Schlossmann J, Hofmann F, Wegener JW. Calcium-dependent and Calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 297, G834-G839, 2009.

Higuchi T, Anton M, Dumler K, Seidl S, Pelisek J, Saraste A, Welling A, Hofmann F, Oostendorp RA, Gansbacher B, Nekolla SG, Bengel FM, Botnar RM, Schwaiger M. Combined Reporter Gene PET and Iron Oxide MRI for Monitoring Survival and Localization of Transplanted Cells in the Rat Heart. J Nucl Med.  50, 1088-94 (2009).

Ahles A, Engelhardt S. Polymorphisms determine beta-adrenoceptor conformation: implications for cardiovascular disease and therapy. Trends Pharmacol Sci. 30, 188-93 (2009).

Frei E, Hofmann F & Wegener JW. Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle. Eur J Pharmacol. 610, 107-09 (2009).

Vilardaga JP, Buenemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ & Hoffmann C. GPCR and G proteins: drug efficacy and activation in live cells. Mol. Endocrinol. 23, 590-99 (2009).

Spiessberger B, Bernhard D, Herrmann S, Feil S, Werner C, Luppa PB, Hofmann F. cGMP-dependent protein kinase II and aldosterone secretion. FEBS J. 276, 1007-13 (2009).

Dorsch S, Klotz K-N, Engelhardt S, Lohse MJ & Bünemann M. Analysis of receptor oligomerization by FRAP microscopy. Nat. Methods. 6, 225-30 (2009).

Lewin G, Matus M, Basu A, Frebel K, Rohsbach SP, Safronenko A, Seidl MD, Stümpel F, Buchwalow I, König S, Engelhardt S, Lohse MJ, Schmitz W & Müller FU. Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction. Circulation. 119, 79-88 (2009).

Hofmann F, Bernhard D, Lukowski R & Weinmeister P. cGMP Regulated Protein Kinases (cGK). Handb. Exp. Pharmacol. 137-62 (2009).

Kleppisch T. Phosphodiesterases in the central nervous system. Handb. Exp. Pharmacol. 71-92 (2009).

Kleppisch T & Feil R. cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour. Handb. Exp. Pharmacol. 549-79 (2009).

Welling A. Voltage-dependent calcium channels. BioTrend Rev. 4, 1-11 (2009).

2008

Paul C, Schöberl F, Weinmeister P, Micale V, Wotjak CT, Hofmann F & Kleppisch T. Signaling through cGMP-dependent protein kinase I in the amygdala is critical for auditory-cued fear memory and long-term potentiation. J Neurosci. 28,14202-14212 (2008)

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J & Engelhardt S. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456, 980-984 (2008).

Feil R & Kleppisch T. NO/cGMP-dependent modulation of synaptic transmission. Handb. Exp. Pharmacol. 184, 529 – 560 (2008).

Cook AR, Bardswell SC, Pretheshan S, Dighe K, Kanaganayagam GS, Jabr RI, Merkle S, Marber MS, Engelhardt S & Avkiran M. Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: A role for ER stress? J. Mol. Cell. Cardiol. Nov 5. [Epub ahead of print] (2008).

Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L. Hofmann  &  Feil R. Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells. Mol. Biol. Cell. 19, 4434 - 4441 (2008).

Lemke T, Welling A, Christel CJ, Blaich A, Bernhard D, Lenhardt P, Hofmann F & Moosmang S. Unchanged ß-adrenergic stimulation of cardiac L-type calcium channels in Cav1.2 phosphorylation site S1928A mutant mice. J. Biol. Chem. 283, 34738-34744 (2008).

Hoesl E, Stieber J, Herrmann S, Feil S, Tybl E, Hofmann F, Feil R & Ludwig A. Tamoxifen-inducible gene deletion in the cardiac conduction system. J. Mol. Cell. Cardiol. 45, 62 – 69 (2008).

Lukowski R, Weinmeister P, Bernhard D, Feil S, Gotthardt M, Herz J, Massberg S, Zernecke A, Weber C, Hofmann F & Feil R. Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis. Arterioscler. Thromb. Vasc. Biol. 28, 1244 – 1250 (2008).

Lacinova L, Moosmang S, Langwieser N, Hofmann F & Kleppisch T. Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells. Life Sciences 82, 41 – 49 (2008).

Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher HD, Hofmann F, Tegeder I, Ruth P & Geisslinger G. Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. J. Neurosci. 28, 1320 – 1330 (2008).

Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U-il & Kawaguchi H. Phosphorylation of GSK-3b by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. J. Clin. Invest. 118, 2506 – 2515 2008).

Föller M, Feil S, Ghoreschi K, Koka S, Gerling A, Thunemann M, Hofmann F, Schuler B, Vogel J, Pichler B, Kasinathan RS, Nicolay JP, Huber,SM, Lang & Feil R. Anemia and splenomegaly in cGKI-deficient mice. PNAS 105, 6771-6776 (2008).

Tippens, A. L. et al. Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus. J Comp Neurol 506, 569-83 (2008).

 

2007

Angstenberger M, Wegener JW, Pichler BJ, Judenhofer MS, Feil S, Alberti S, Feil R & Nordheim A. Severe instestinal obstruction on induced smooth musle-specific ablation of the transcription factor SRF in adult mice. Gastroenterology 133, 1948 – 1959 (2007).

Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S & Schlossman J. IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109, 552 – 559 (2007).

Azebaze AGB, Dongmo AB, Meyer M, Ouahouo BMW, Valentin A, Nguemfo EL, Nkengfack AE & Vierling W. Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola(Guttiferae). Ann. Trop. Med. and Parasitol. 101, 23-30 (2007).

Döring B, Pfitzer G, Adam B, Liebregts T, Eckardt D, Holtmann G, Hofmann F, Feil S, Feil R & Willecke K. Ablation of connexin43 in smooth muscle cells of the mouse intestine: functional insights into physiology and morphology. Cell Tissue Res. 327, 333 – 342 (2007).

Dongmo AB, Azebaze AGB, Nguelefack TB, Ouahouo BM, Sontia B, Meyer M, Nkengfack AE, Kamanyi A & Vierling W. Vasodilator effect of the extracts and some coumarins from the stem bark of Mammea africana (Guttiferae). J. Ethnopharmacol. 111, 329 – 334 (2007).

Engelhardt S. Alternative signaling: cardiomyocyte beta1-adrenergic receptors signal through EGFRs. J. Clin. Invest. 117, 2396-2398. (2007).

Engelhardt S & Rochais F. G proteins: more than transducers of receptor-generated signals? Circ. Res. 100, 1109- 1111 (2007).

Essin K, Welling A, Hofmann F, Luft FC, Gollasch M & Moosmang, S. Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca 2+ sparks in murine arterial smooth muscle cells. J. Physiol. 584, 205 – 219 (2007).

Frost RJ & Engelhardt S. A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart. Circulation 116, 1768-1775. (2007).

Held B, Tsvilovskyy V, Meissner M, Kaestner L, Ludwig A, Moosmang S, Lipp P, Freichel M & Flockerzi V. Ca2+ channel currents and contraction in Ca-V beta (3)- deficient ileum smooth muscle from mouse. Cell Calcium 42, 477-487 (2007).

Herrmann S, Stieber J, Stöckl G, Hofmann F & Ludwig A. HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J. 26, 4423 – 4432 (2007).

Merkle S, Frantz S, Schön MP, Bauersachs J, Buitrago M, Frost RJ, Schmitteckert EM, Lohse MJ & Engelhardt S. A role for caspase-1 in heart failure. Circ Res. 100, 645-653 (2007).

Moosmang S, Kleppisch T, Wegener J, Welling A & Hofmann F. Analysis of calcium channels by conditional mutagenesis. Handb. Exp. Pharmacol. 178, 469 – 490 (2007).

Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE.
Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1 adrenergic receptor. J. Clin. Invest. 117, 1335-1343 (2007).

Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ & Engelhardt S. Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J. Clin. Invest. 117, 29-235 (2007).

Rohrbach S, Engelhardt S, Lohse MJ, Werdan K, Holtz J & Muller-Werdan U. Activation of AP-1 Contributes to the beta-Adrenoceptor-Mediated Myocardial Induction of Interleukin-6. Mol. Med. 13, 605-614 (2007).

Sausbier M, Zhou XB, Beier C, Sausbier U, Wolpers D, Maget S, Martin C, Dietrich A, Ressmeyer AR, Renz H, Schlossmann J, Hofmann F, Neuhuber W, Gudermann T, Uhlig S, Korth M & Ruth P. Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+ - activated K+ channel. FASEB J. 21, 812 – 822 (2007).

Schmidt H, Stonkute A, Jüttner, R, Schäffer S, Buttgereit J, Feil R, Hofmann F & Rathjen FG. The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J. Cell Biol. 179, 331 – 340 (2007).

Seeland U, Selejan S, Engelhardt S, Müller P, Lohse MJ & Böhm M. Interstitial remodeling in beta1-adrenergic receptor transgenic mice. Basic Res. Cardiol. 102, 183-193 (2007).

Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G & Bauersachs J. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 116, 258-267, 2. Erratum in: Circulation 116 (2007).

Weber S, Bernhard D, Lukowski R, Weinmeister P, Wörner R, Wegener JW, Valtcheva N, Feil S, Schlossmann J, Hofmann F & Feil R. Rescue of cGMP kinase I knockout mice by smooth muscle-specific expression of either isozyme. Circ. Res. 101, 1096 – 1103 (2007).

Wörner R, Lukowski R, Hofmann F & Wegener JW. cGMP signals mainly through cAMP kinase in permeabilized murine aorta. Am. J. Phsyiol. Heart Circ. Physiol. 292, H237 – H244 (2007).

Ying SW, Jia F, Abbas SY, Hofmann F, Ludwig A & Goldstein PA. Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons. J. Neurosci. 27, 8719 – 8732 (2007).

2006

Azebaze AGB, Dongmo AB, Meyer, M, Ouahouo BMW, Valentin A, Nguemfo EL, Nkengfack AE & Vierling W. Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae). Ann. Trop. Med. and Parasitol. 100, 1 – 8 (2006).

Boesten LS, Zadelaar SM, de Clercq S, Francoz S, van Nieuwkoop A, Biessen EAL, Hofmann F, Feil S, Feil R, Jochemsen AG, Zurcher C, Havekes LM, van Vlijmen BJM & Marine JC. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated-caspase-3-independent cell death. Cell Death Differ. 13, 2089 – 2098 (2006).

Bryan PM, Smirnov D, Smolenski A, Feil S, Feil R, Hofmann F, Lohmann S & Potter LR. A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-I a does not regulate NPR-A. Biochem. 45, 1295 – 1303 (2006).

Döring B, Shynlova O, Tsui P, Eckardt D, Janssen-Bienhold U, Hofmann F, Feil S, Feil R, Lye SJ & Willecke K. Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition. J. Cell Sciences 119, 1715 – 1722 (2006).

Fiedler B, Feil R, Hofmann F, Willenbockel C, Drexler H, Smolenski A, Lohmann SM & Wollert KC. cGMP-dependent protein kinase Type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. J. Biol. Chem. 281, 32831 – 32840 (2006).

Gomes B, Savignac M, Cabral MD, Paulet P, Moreau M, Leclerc C, Feil R, Hofmann F, Guéry JC, Dietrich G & Pelletier L. The cGMPprotein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes. J. Biol. Chem. 281, 12421 - 12427 (2006).

Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ & Bünemann M. Gs activation is time-limiting in initiating receptor-mediated signaling. J. Biol. Chem. 281, 33345-33351 (2006).

Hofmann F, Feil R, Kleppisch T & Schlossmann J. Function of cGMP-dependent protein kinases as revealed by gene deletion. Physiol. Rev. 86, 1 – 23 (2006).

Lacinova L, Kurejova M, Klugbauer N & Hofmann F. Gating of the expressed T-type Cav3.1 calcium channels is modulated by Ca2+. Acta Physiol. 186, 249 – 260 (2006).

Lee TS, Karl R, Moosmang S, Lenhardt P, Klugbauer N, Hofmann F, Kleppisch T & Welling A. Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel. J. Biol. Chem. 281, 25560-25567 (2006).

Moosmang S, Haider N, Brüderl B, Welling A & Hofmann F. Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2. Circ. Res. 98, 105 – 110 (2006).

Meuth SG, Kanyshkova T, Meuth P, Landgraf P, Munsch T, Ludwig A, Hofmann F,Pape HC &Budde, T. Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels. J. Neurophysiol. 96, 1517 – 1529 (2006).

Nikolaev VO, Bünemann M, Schmitteckert E, Lohse MJ & Engelhardt S. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ. Res. 99, 1084-1091 (2006).

Nguelefack TB, Sontia B, Dongmo AB, Dimo T, Kamanyi A & Vierling W. Spasmolytic effects of extracts from Kalanchoe crenata andrews (Crassulaceae) leaves. Pharmacologyonline 1, 30 – 39 (2006).

Stieber J, Wieland K, Stöckl G, Ludwig A & Hofmann F. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol. Pharmacol. 69, 1328 – 1337 (2006).

Vierling W. Besonderheiten der Arnzeimittelanwendung im Alter. In: Medizin des Alterns und des alten Menschen, Hrsg. Werner Hansen, Schattauer Verlag Stuttgart, 94 – 115 (2006).

Vignali S, Leiss V, Karl R, Hofmann F & Welling A. Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J. Physiol. 527, 691 – 706 (2006).

Wegener J, Schulla V, Koller A, Klugbauer N, Feil R & Hofmann F. Control of intestinal motility by the Cav1.2 L-type calcium channel in mice. FASEB J. 20, 1260 – 1262 (2006).

2005

Bijvelds MJ, Jorna H, Verkade HJ, Bot AG, Hofmann F, Agellon LB, Sinaasappel M & de Jonge JR. Activation of CFTR by ASBT-mediated bile salt absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G870 – G879 (2005).

Buitrago M, Lorenz K, Maass AH, Oberdorf-Maass S, Keller U, Schmitteckert EM, Ivashchenko Y, Lohse MJ & Engelhardt S. The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Nat. Med. 11, 837-844 (2005).

Demyanenko GP, Halberstadt AI, Pryzwansky KB, Werner C, Hofmann F & Maness PF. Impaired neocortical organization in mice lacking cGMP-dependent protein kinase I. Brain Res. Dev. Brain Res. 160, 1 – 8 (2005).

Engelhardt S. Beta-adrenergic receptors in heart failure. Heart Fail Clin. 1, 183-191 Review (2005).

Feil R, Feil S & Hofmann F. A heretical view on the role of NO and cGMP in vascular proliferative diseases. Trends in Molecular Medicine 111, 71 – 75 (2005).

Feil R, Hofmann F &. Kleppisch T. Function of cGMP-dependent protein kinases in the nervous system. Rev. Neurosci. 16, 23 – 41 (2005).

Feil S, Zimmermann P, Knorn A, Brummer S, Schlossmann J, Hofmann F & Feil R. Distribution of cGMP-dependent protein kinase Type I and its isoforms in the mouse brain and retina. Neurosci. 135, 863 – 868 (2005).

Frambach T, Müller T, Freund S, Engelhardt S, Sütterlin M, Lohse MJ & Dietl J. Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling. J. Clin. Endocrino.l Metab. 90, 2882-2887 (2005).

Herrmann S, Stieber J, Ludwig A & Hofmann F. Schrittmacherkanäle: Wächter an Hirn und Herz. Jahrbuch 2004 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale) 50, 421 – 428 (2005).

Hofmann F. The biology of cyclic GMP-dependent protein kinases. J. Biol. Chem. 280, 1 – 4 (2005).

Hofmann F, Biel M & Kaupp B. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. Pharmacol. Rev. 57, 455 – 462 (2005).

Lacinova L & Hofmann F. Ca2+ -and voltage-dependent inactivation of the expressed L-type Cav1.2 calcium channel. Arch. of Biochemistr. and Biophys, 437, 42 – 50 (2005).

Lukowski R, Weber S, Weinmeister P, Feil S & Feil R. Cre/loxP-vermittelte konditionale Mutagenese des cGMP-Signalwegs in der Maus. Biospektrum 3, 287 – 290 (2005).

Michalakis S, Geiger H, Haverkamp S, Hofmann F, Gerstner A & Biel M. Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3. Invest. Ophthalmol. & Visual Science 46, 1516 – 1524 (2005).

Moosmang S, Haider N, Klugbauer N, Adelsberger H, Langwieser N, Müller J, Stiess M, Marais E, Schulla V, Lacinova L, Goebbels S, Nave KA, Storm DR, Hofmann F & Kleppisch T. Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J. Neurosci. 25, 9883 – 9892 (2005).

Moosmang S, Lenhardt P, Haider N, Hofmann F & Wegener JW. Mouse models to study L-type calcium channel function. Pharmacol. & Therap. 106, 347 – 355 (2005).

Nikolaev VO, Gambaryan S, Engelhardt S, Walter U & Lohse MJ. Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. J. Biol. Chem. 280, 1716-1719 (2005).

Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Adullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M & Ruth P. Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circ. 112, 60 – 68 (2005).

Schlossmann J, Feil R & Hofmann F. Insights into cGMP signalling derived from cGMP kinase knockout mice. Frontiers in Bioscience 10, 1279 – 1289 (2005).

Schlossmann J & Hofmann F. cGMP-dependent protein kinases in drug disvovery. DDT 10, 627 – 634 (2005).

Stieber J. Bedeutung des Schrittmacherkanals HCN4 im embryonalen Herzen der Maus. Biospektrum 2, 213 – 214 (2005).

Stieber J, Stöckl G, Herrmann S, Hassfurth B & Hofmann F. Functional expression of the human HCN3 channel. J. Biol. Chem. 280, 34635 – 34643 (2005).

Vierling W, Sontia B, Müller B & Wagner H. Effects of polyphenols and magnesium on functions of heart and vascular smooth muscle: similarities and differences. In: Biopolyphenol und Magnesium – Südsteirische Schätze (eds S. Porta and D. Gualtieri). 1st edition, 104 – 116 (Edition B, Graz, Österreich, 2005).

Vierling W. 25th Magnesium-Symposium of the Society of Magnesium Research, 8.-9. Okt. 2004 in München. J. Trace Elem. Electrolytes Health Dis. 22, 160 – 168 (2005).

Welling A, Hofmann F & Wegener JW. Inhibition of L-type Cav1.2 Ca2+ -channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Gö6983). Mol. Pharmacol. 67, 541 – 544 (2005).

Werner CG, Godfrey V, Arnold RR, Featherstone GL, Bender D, Schlossmann J, Schiemann M, Hofmann F & Pryzwansky KB. Neutrophil dysfunction in guanosine 3`,5`-cyclic monophosphate-dependent protein kinase I-deficient mice. J. Immunol. 175, 1919 –1929 (2005).

2004

Biel M & Hofmann F. Cyclic Nucleotide-Regulated Cation Channels. In: Encyclopedia of Biological Chemistry; eds. Lennarz, W. u. Lane, M.D., Elsevier Science (USA), Volume 1, 512-515 (2004).

Brill J, Klocke R, Paul D, Boison D, Gouder N, Klugbauer N, Hofmann F, Becker CM & Becker K. Entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. J. Biol. Chem. 279, 7322 – 7330 (2004).

Dongmo A, Kamanyi MA, Tan PV, Bopelet M, Vierling W & Wagner H. Vasodilating properties of the stem bark extract of Mitragyna ciliata in rats and guinea pigs. Phytother. Res. 18, 36 – 39 (2004).

Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G & Lohse MJ. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation. 109, 1154-1160 (2004).

Feil S, Hofmann F & Feil R. SM22a Modulates vascular smooth muscle cell phenotype during atherogenesis. Circ. Res. 94, 863 – 865 (2004).

Foerster K, Kaeferstein T, Groner F, Engelhardt S, Matthes J, Koch WJ, Lohse MJ & Herzig S. Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice. Naunyn Schmiedebergs Arch. Pharmacol. 369, 490-5 (2004).

Fritsch R, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhöringer A, Hofmann F & Allescher HD. InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. J. Biol. Chem. 279, 12551-12559 (2004).

Geiselhöringer A, Gaisa M, Hofmann F & Schlossmann J. Distribution of IRAG and cGKI-isoforms in murine tissues. FEBS Lett. 575, 19 – 22 (2004).

Geiselhöringer A, Werner M, Sigl K, Smital P, Wörner R, Acheo L, Stieber J, Weinmeister P, Feil R, Feil S, Wegener J, Hofmann F & Schlossmann J. IRAG is essential for relaxation of receptor-triggered smooth musle contraction by cGMP kinase. EMBO J. 23, 4222-4231 (2004).

Hofmann F. Wirkungen von Pharmaka auf den Organismus: allgemeine Pharmakodynamik. In: Allgemeine und spezielle Pharmakologie und Toxikologie, Eds. Aktories, Förstermann, Hofmann, Starke, 9. Auflage, Urban & Fischer – Verlag, 5 – 25 (2004).

Hofmann F. Wächter am Herz und Bewußtsein – Schrittmacherkanäle (Pacemaker Channels and the Control of Heart Rhythm and Awarness. Sitzungsberichte der Bayerischen Akademie der Wissenschaften, Jahrgang 2001 – 2003, Verlag C.H. Beck, München, 16 – 17 (2004).

Hofmann F, Biel M, Feil R & Kleppisch T. Mouse Models of NO/Natriuretic Peptide/cGMP Kinase Signaling. In: Transgenic Models in Pharmacology” Eds. Stefan Offermanns u. Lutz Hein, Handbook of Experimental Pharmacology, Springer – Verlag, Vol.159, 95 –130 (2004).

Hofmann F & Stieber J. Molecular basis of pacemaking. In: “Rezeptoren – Mediatoren, Ihre Rolle bei modernen Therapieansätzen, Eds. Michel und Wolf, Schattauer Verlag, 71 – 81 (2004).

Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U & de Wit C. cGMP-dependent protein kinase mediates NO- but not ACh-induced dilations in resistance vessels in vivo. Hypertension. 44, 952 – 955 (2004).

Ludwig A, Stieber J, Moosmang S, Herrmann S, Biel M & Hofmann F. HCN Channels: From genes to function. In „Cardiac Electrophysiology“ From Cell to Bedside, Eds. Zipes & Jalife, 4th Ed., Saunders, 59 – 65 (2004).

Marshall SJ, Senis YA, Auger JM, Feil R, Hofmann F, Salmon G, Perterson,JT, Burslem F & Watson SP. GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase. Blood 103, 2601 – 2609 (2004).

Otto C, Hein L, Brede M, Jahns R, Engelhardt S, Gröne HJ & Schütz G. Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice. Circulation. 110, 3245-3251 (2004).

Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF & Ruth P. Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. PNAS 101, 9474 – 9478 (2004).

Spedding M, Foord SM & Hofmann F. Current status of drug receptor nomenclature: receptor closure? The role of NC-IUPHAR. Expert Opin. Investig. Drugs 13, 461 – 464 (2004).

Stieber J, Hofmann F & Ludwig A. Pacemaker channels and sinus node arrthythmia. Trends Cardiovas. Med. 14, 23 – 28 (2004).

Tegeder I, Del Turco D, Schmidtko A, Sausbier M, Feil R, Hofmann F, Deller T, Ruth P. & Geisslinger G. Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. PNAS 101, 3253 – 3257 (2004).

Vierling W. Institut für Pharmakologie und Toxikologie, Fakultät für Medizin der Technischen Universität München. In: Geschichte und Wirken der pharmakologischen, klinisch – pharmakologischen und toxikologischen Institute im deutschsprachigen Raum, Ed. A. Philippu, Beerenkamp Verlag Innsbruck, 542 – 546 (2004).

Wegener JW, Schulla V, Lee TS, Koller A, Feil S, Feil R, Kleppisch T, Klugbauer N, Moosmang S, Welling A & Hofmann F. An essential role of Cav1.2 L-type calcium channel for urinary bladder function. FASEB J. 18, 1159 – 1161 (2004).

Werner C, Raivich G, Cowen M, Stekalowa T, Sillaber I. Buters JT, Spanagel R & Hofmann F. Importance of NO/cGMP signaling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. Eur. J. Neurosci . 20, 3498 – 3506 (2004).

Witte K, Engelhardt S, Janssen BJ, Lohse M & Lemmer B. Circadian and short-term regulation of blood pressure and heart rate in transgenic mice with cardiac overexpression of the beta1-adrenoceptor. Chronobiol. Int. 21, 205-216 (2004).

Zerkowski HR, Grussenmeyer T, Matt P, Grapow M, Engelhardt S & Lefkovits I. Proteomics strategies in cardiovascular research. J. Proteome Res. 3, 200-2008 Review (2004).

2003

Dongmo AB, Ndom JC, Massoma LD, Dzikouk DG, Fomani M, Kamanyi A & Vierling W. Vasodilating effect of the root bank extract of Ficus saussureana on guinea pig aorta. Pharm. Biol. 41, 371 – 374 (2003).

Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U & Hein L. Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 285, H2471-H2481 (2003).

Er F, Larbig R, Ludwig A, Biel M, Hofmann F, Beuckelmann DJ & Hoppe UC. Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current If and undermines spontaneous beating of neonatal cardiomyocytes. Circulation 107, 485 – 489 (2003).

Feil R, Hartmann J, Luo C, Wolfsgruber W, Schilling K, Feil S, Barski JJ, Meyer M, Konnerth A, de Zeeuw CI & Hofmann F. Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J. Cell Biology 163, 295 – 302 (2003).

Feil R, Lohmann SM, de Jonge H, Walter U & Hofmann F. Cyclic GMP-dependent protein kinases and the cardiovascular system: Insights from genetically modified mice. Circ Res. 93, 907 – 916 (2003).

Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF & Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108, 2926-2933 (2003).

Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG & Yau KW. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424, 76 – 81 (2003).

Hofmann F. Smooth muscle tone regulation. In: Encyclopedic Reference of Molecular Pharmacology, Eds. Stefan Offermanns u. Walter Rosenthal, Springer Verlag, 870 – 875 (2003).

Hofmann F. Voltage-dependent Ca2+ - channels. In: Encyclopedic Reference of Molecular Pharmacology, Eds. Stefan Offermanns u. Walter Rosenthal, Springer Verlag, 994 - 999 (2003).

Hofmann F, Biel M & Kaupp B. International Union of Pharmacology XLII. Compendium of voltage-gated ion channels: cyclic nucleotide-modulated channels. Pharmacol. Rev. 55, 587 – 589 (2003).

Hofmann F, Feil R, Kleppisch T & Werner C. Effects of cGMP – dependent protein kinase knockouts. Handbook of Cell Signaling, ed. R. Bradshaw and E. Dennis, Academic Press, Vol. 2 , 511 – 514 (2003).

Kamanyi A, Dongmo AB, Salah MA, Jatsa H, Wagner H, Vierling W & Bopelet M. Endothelium mediated aortic relaxation and blood pressure lowering effect of a procyanidin rich fraction of the stembark extracts of Erythrophleum suaveolens. Pharm. Biol. 41, 62 – 67 (2003).

Kleppisch T, Wolfsgruber W, Feil S, Allmann R, Wotjak C, Goebbels S, Nave KA, Hofmann F & Feil R. Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory. J. Neurosci. 23, 6005 – 6012 (2003).

Klugbauer N, Marais E & Hofmann F. Calcium channel a2d subunits: Differential expression, function and drug binding. J. Bioenerg. and Biomembr. 35, 639 – 647 (2003).

Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P & Hofmann F. Association of phospholamban with a cGMP kinase signaling complex. Biochem. Biophys. Res. Comm. 300, 155 – 160 (2003).

Li Z, Xi X, Gu M, Feil R, Ye R, Eigenthaler M, Hofmann F & Du X. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 112, 77 – 86 (2003).

Lohse MJ, Engelhardt S & Eschenhagen T. What is the role of beta-adrenergic signaling in heart failure? Circ. Res. 93, 896-906 Review (2003).

Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthof, K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M & Hofmann F. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 22, 216 – 224 (2003).

Maack C, Böhm M, Vlaskin L, Dabew E, Lorenz K, Schäfers HJ, Lohse MJ & Engelhardt S.
Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor. Circulation. 108, 348-353 (2003).

Mempel M, Isa G, Klugbauer, N, Meyer H, Wildi G, Ring J, Hofmann F & Hofmann H. Laboratory acquired infection with recombinant vaccinia virus containing an immunomodulating construct. J. Invest. Dermatol. 120, 356 – 358 (2003).

Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F & Klugbauer N. Dominant role of smooth muscle L-type calcium channel Cav 1.2 role blood pressure regulation. EMBO J. 22, 6027 – 6034 (2003).

Mullershausen F, Friebe A, Feil R, Thompson WJ, Hofmann F & Koesling D. Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling. J. Cell. Biol. 160, 719 – 727 (2003).

Münzel T, Feil R, Mülsch A, Lohmann SM, Hofmann F & Walter U. Physiology and Pathophysiology of vascular signaling controlled by cyclic guanosine 3´,5´-cyclic monophosphate-dependent protein kinase. Circulation 108, 2172 – 2183 (2003).

Oster H, Werner C, Magnone M C, Mayser H, Feil R, Seeliger MW, Hofmann F & Albrecht U. cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock. Curr. Biol. 13, 725 – 733 (2003).

Schlossmann J, Feil R & Hofmann F. Signaling through NO and cGMP-dependent protein kinases. Ann. Med. 35, 21 – 27 (2003).

Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P & Hofmann F. Impaired insulin secretion and glucose tolerance in β cell-selective Cav1.2 Ca2+-channel null mice. EMBO J. 22, 3844 – 3854 (2003).

Shimizu-Albergine M, Rybalkin SD, Rybalkina IG , Feil R, Wolfsgruber W, Hofmann F & Beavo JA. Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): In Vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation. J. Neurosci. 23, 6452 – 6459 (2003).

Stieber J, Herrmann S, Feil S, Löster J, Feil R, Biel M, Hofmann F & Ludwig A. The hyperpolariation-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. PNAS 100, 15235 – 15240 (2003).

Spindler M, Engelhardt S, Niebler R, Wagner H, Hein L, Lohse MJ & Neubauer S. Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice. J. Mol. Cell. Cardiol.35, 389-397 (2003).

Stieber J, Thomer A, Much B, Schneider A, Biel M & Hofmann F. Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4*. J. Biol. Chem. 278, 33672 – 33680 (2003).

Talavera K, Janssens A, Klugbauer N, Droogmans G & Nilius B. Pore structure influences gating properties of the T-type Ca2+ channel a1G. J. Gen. Physiol. 121, 529 – 540 (2003).

Talavera K, Janssens A, Klugbauer N, Droogmans G & Nilius B. Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel a1G (Cav3.1). J. Gen. Physiol. 121, 511 – 528 (2003).

Vaandrager AB, Hogema BM, Edixhoven M, van den Burg CMM, Bot AGM, Klatt P, Ruth P, Hofmann F, van Damme J, Vandekerckhove J & de Jonge HR. Autophosphorylation of cGMP-dependent Protein Kinase Type II. J. Biol. Chem. 278, 28651 – 28658 (2003).

Vierling W, Brand N, Gaedcke F, Sensch KH, Schneider E & Scholz M. Investigation of the pharmaceutical and pharmacological equivalence of different Hawthorn extracts*. Phytomedicine 10, 8 – 16 (2003).

Wegener JW, Korstanje C & Nawrath H. Voltage-dependent effects of barnidipine in rat vascular smooth muscle. J. Cardiovasc. Pharmacol. 42, 218 – 223 (2003).

Wegener JW, Lee M & Hofmann F. Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus. Can. J. Physiol. Pharmacol. 81, 890 – 893 (2003).

Wolfsgruber W, Feil S, Brummer S, Kuppinger O, Hofmann F & Feil R. A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells. PNAS 100, 13519 – 13524 (2003).

Xu M, Welling A, Paparisto S, Hofmann F & Klugbauer N. Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice*. J. Biol. Chem. 278, 40837 – 40841 (2003).