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17.11.2016

Congrats to Deepak Ramanujam on his newest publication on "Viral Vector-Based Targeting of miR-21" in Molecular Therapy! Read more.

17.11.2016

We congratulate Ivana on successfully completing her Master's Thesis. We wish her all the best for the future.

16.11.2016

Stefan Engelhardt re-elected vice dean of research. On November 16th, the TUM Faculty of Medicine has elected its new faculty board. Stefan Engelhardt, was re-elected as Vice Dean for Research (‚Beauftragter für Forschung‘) for another period of three years.

17.10.2016

Angela has successfully completed her internship in our department.We wish her all the best for her future career!

02.09.2016

Congrats to Stanislas Werfel on his newest publication on "Characterization of circular RNAs in human, mouse and rat hearts" in Journal of Molecular and Cellular Cardiology! Read more.

01.07.2016

Dr. Vanessa Philippi recently joined our staff as an approbated veterinarian. Welcome aboard!

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis

(May 2016) Fibrosis is marked by excessive deposition of extracellular matrix and uncontrolled formation of connective tissue, both leading to morphologic changes that impair heart function. In a study published in the undefinedJournal of the American College of Cardiology Kathleen Meyer et al. (Sarikas laboratory) identified non-age-related premature senescence of myofibroblasts as novel anti-fibrotic mechanism in the heart. By using different animal models of cardiac diseases, together with human heart biopsies, the authors showed that myofibroblasts undergo premature senescence in the course of fibrogenesis. Genetic inactivation of the cellular senescence program resulted in aggravated fibrosis and cardiac dysfunction. In contrast, heart-specific induction of senescence limited fibrosis and had cardioprotective effects. Collectively, this study establishes premature senescence of myofibroblasts as essential anti-fibrotic mechanism and potential therapeutic target in myocardial fibrosis.  

For further information please contact PD Dr. Antonio Sarikas (antonio.sarikas(at)tum.de)

Use of Learning Media by Undergraduate Medical Students in Pharmacology: A Prospective Cohort Study

(April 2015) In a study published in the current issue of PLOS ONE, Joanna Gutmann (AG Dr. Sarikas) provides a comprehensive assessment of learning media use by undergraduate medical students in pharmacology. Using a prospective mixed-method design with daily online surveys and final semi-structured interviews, the authors demonstrate a preponderance of digital resources for learning by both male and female students in pharmacology. Ms Gutmann and co-workers show that students employ a broad spectrum of learning media, of which lecture slides, apps and personal notes were most utilized, followed by textbooks (> 300 pages), internet search and e-learning cases. Finally, the results of this study indicate that students`use of some learning resources is dynamic and varies between teaching and self-study periods.